Profile-based short linear protein motif discovery
نویسندگان
چکیده
منابع مشابه
The SLiMDisc server: short, linear motif discovery in proteins
Short, linear motifs (SLiMs) play a critical role in many biological processes, particularly in protein-protein interactions. Overrepresentation of convergent occurrences of motifs in proteins with a common attribute (such as similar subcellular location or a shared interaction partner) provides a feasible means to discover novel occurrences computationally. The SLiMDisc (Short, Linear Motif Di...
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Many important interactions of proteins are facilitated by short, linear motifs (SLiMs) within a protein's primary sequence. Our aim was to establish robust methods for discovering putative functional motifs. The strongest evidence for such motifs is obtained when the same motifs occur in unrelated proteins, evolving by convergence. In practise, searches for such motifs are often swamped by mot...
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Motif Finding is one of the important tasks in gene regulation which is essential in understanding biological cell functions. Based on Tompa et al. study, the performance of current motif finders is not satisfactory. A number of ensemble methods has been proposed to enhance the results. Existing ensemble methods overall performance is better than stand-alone motif finders. A recent ensemble met...
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AUTOMATED DATA-DRIVEN DISCOVERY OF MOTIF-BASED PROTEIN FUNCTION CLASSIFIERS Xiangyun Wang, Diane Schroeder, Drena Dobbs, and Vasant Honavar Artificial Intelligence Laboratory Department of Computer Science and Graduate Program in Bioinformatics and Computational Biology Iowa State University Ames, IA 50011, USA www.cs.iastate.edu/~honavar/aigroup.html [email protected] ABSTRACT This paper ...
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The development of novel analytical tools to investigate the structure of music works is central in current music information retrieval research. In particular, music summarization aims at finding the most representative parts of a music piece (motifs) that can be exploited for an efficient music database indexing system. Here we present a novel approach for motif discovery in music pieces base...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2012
ISSN: 1471-2105
DOI: 10.1186/1471-2105-13-104